Endocrine Abstracts

Background: Hypovitaminosis D is associated with T2DM risk, cross-sectionally and prospectively; supplementation can reduce insulin resistance and increase glucose-induced insulin secretion in humans. Increased pancreatic islet RAS activity is induced by hyperglycemia, enhancing β cell damage (Leung PS et al.). Vitamin D is now known to suppress renin secretion, thus we have examined effects of calcitriol on increased islet RAS activity in vitro±hyp...